Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers.

ABSTRACT: The myotendinous junction (MTJ) is structurally specialized to transmit force. The highly folded muscle membrane at the MTJ increases the contact area between muscle and tendon and potentially the load tolerance of the MTJ. Muscles with a high content of type II fibers are more often subject to strain injury compared with muscles with type I fibers. It is hypothesized that this is explained by a smaller interface area of MTJ in type II compared with type I muscle fibers. The aim was to investigate by confocal microscopy whether there is difference in the surface area at the MTJ between type I and II muscle fibers. Individual muscle fibers with an intact MTJ were isolated by microscopic dissection in samples from human semitendinosus, and they were labeled with antibodies against collagen X

SUBMITTER: Jakobsen JR 

PROVIDER: S-EPMC10091713 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature