Fetal thoracic circumference in mid-pregnancy and infant lung function.

ABSTRACT:

Background and aim

Impaired lung function in early infancy is associated with later wheeze and asthma, while fetal thoracic circumference (TC) predicts severity of neonatal lung hypoplasia. Exploring fetal origins of lung function in infancy, we aimed to determine if fetal TC in mid-pregnancy was associated with infant lung function.

Methods

From the prospective Scandinavian general population-based PreventADALL mother-child birth cohort, all 851 3-month-old infants with tidal flow-volume measurements in the awake state and ultrasound fetal size measures at 18 (min-max 16-22) weeks gestational age were included. Associations between fetal TC and time to peak tidal expiratory flow to expiratory time (t_PTEF /t_E ) were analyzed in linear regression models.

SUBMITTER: Gudmundsdottir HK 

PROVIDER: S-EPMC10091718 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature