Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise.

ABSTRACT: Cancer cachexia is defined as a multi-factorial syndrome characterised by an ongoing loss of skeletal muscle mass and progressive functional impairment, estimated to affect 50-80% of patients and responsible for 20% of cancer deaths. Elevations in the morbidity and mortality rates of cachectic cancer patients has been linked to respiratory failure due to atrophy and dysfunction of the ventilatory muscles. Despite this, there is a distinct scarcity of research investigating the structural and functional condition of the respiratory musculature in cancer, with the majority of studies exclusively focusing on limb muscle. Treatment strategies are largely ineffective in mitigating the cachectic state. It is now widely accepted that an efficacious intervention will likely combine elements of pha

SUBMITTER: Murphy BT 

PROVIDER: S-EPMC10091733 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature