Somatic and germline aberrations in homologous recombination repair genes in Chinese prostate cancer patients.

ABSTRACT:

Simple summary

Somatic and germline aberrations in homologous recombinant repair (HHR) genes are associated with increased incidence and poor prognosis for prostate cancer. Through next-generation sequencing of prostate cancer patients across all clinical states from north China, here the authors identified a somatic mutational rate of 3% and a germline mutational rate of 3.9% for HRR genes using 200 tumor tissues and 714 blood specimens. Thus, mutational rates in HRR genes were lower compared with previous studies.

Background

Homologous recombination repair deficiency is associated with higher risk and poorer prognosis for prostate cancer. However, the landscapes of somatic and germline mutations in these genes remain poorly defined in Chinese patients, especially for those

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10091863 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature