HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

ABSTRACT: Regulatory T cells (Tregs) are critical for generating and maintaining peripheral tolerance. Treg-based immunotherapy is valuable for the clinical management of diseases resulting from dysregulation of immune tolerance. However, the lack of potency is a potential limitation of Treg therapy. In addition, CD69 positive-Treg (CD69⁺ Treg) represent a newly identified subset of Tregs with potent immune suppressive capability. Methods: Foxp3 ^YFP-Cre CD69 ^fl/fl and CD4 ^Cre CD69 ^fl/fl mice were generated to determine the relevance of CD69 to Treg. Chromatin Immunoprecipitation Assay (ChIP) and luciferase Assay were performed to detect the regulation of CD69 transcription by heat shock transcription factor 1(H

SUBMITTER: Yu L 

PROVIDER: S-EPMC10091886 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature