Prophylaxis use of clotting factor replacement products in people with non-severe haemophilia: A review of the literature.

ABSTRACT:

Introduction

People with non-severe haemophilia appear to be under-treated in many countries, and this may lead to joint damage and worsen quality of life.

Aim

To review literature for clotting factor replacement prophylaxis in people with non-severe haemophilia A and B (HA/HB) in relation to long-term outcomes to support clinical decision-making.

Methods

A targeted literature search was performed to identify studies published between 2000 and 2021 that included prophylaxis in people with non-severe HA/HB and long-term outcomes, including annualized bleeding rates, joint health and quality of life.

Results

Although eligible articles included 2737 and 2272 people with mild or moderate HA, respectively, only 22% (n = 609) and 29% (n = 668) reported treatment regi

SUBMITTER: Iorio A 

PROVIDER: S-EPMC10091955 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature