Chloride Binding Modulated by Anion Receptors Bearing Tetrazine and Urea.

ABSTRACT: Modulation and fine-tuning of the strength of weak interactions to bind anions are described in a series of synthetic receptors. The general design of the receptors includes both a urea motif and a tetrazine motif. The synthetic sequence towards three receptors is detailed. Impacts of H-bond strength and linker length between urea and tetrazine on chloride complexation are studied. Binding properties of the chloride anion are examined in both the ground and excited states using a panel of analytical methods (NMR spectroscopy, mass spectrometry, UV/Visible spectroscopies, and fluorescence). A ranking of the receptors by complexation strength has been determined, allowing a better understanding of the structure-properties relationship on these compounds.

SUBMITTER: Plais R 

PROVIDER: S-EPMC10091995 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature