Facilitation-inhibition control of motor neuronal persistent inward currents in young and older adults.

ABSTRACT: A well-coordinated facilitation-inhibition control of motor neuronal persistent inward currents (PICs) via diffuse neuromodulation and local inhibition is essential to ensure motor units discharge at required times and frequencies. Present best estimates indicate that PICs are reduced in older adults; however, it is not yet known whether PIC facilitation-inhibition control is also altered with ageing. We investigated the responses of PICs to (i) a remote handgrip contraction, which is believed to diffusely increase serotonergic input onto motor neurones, and (ii) tendon vibration of the antagonist muscle, which elicits reciprocal inhibition, in young and older adults. High-density surface electromyograms were collected from soleus and tibialis anterior of 18 young and 26 older adults durin

SUBMITTER: Orssatto LBR 

PROVIDER: S-EPMC10092053 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature