Methods for drug safety signal detection using routinely collected observational electronic health care data: A systematic review.

ABSTRACT:

Purpose

Signal detection is a crucial step in the discovery of post-marketing adverse drug reactions. There is a growing interest in using routinely collected data to complement established spontaneous report analyses. This work aims to systematically review the methods for drug safety signal detection using routinely collected healthcare data and their performance, both in general and for specific types of drugs and outcomes.

Methods

We conducted a systematic review following the PRISMA guidelines, and registered a protocol in PROSPERO. MEDLINE, EMBASE, PubMed, Web of Science, Scopus, and the Cochrane Library were searched until July 13, 2021.

Results

The review included 101 articles, among which there were 39 methodological works, 25 performance assessment papers, a

SUBMITTER: Coste A 

PROVIDER: S-EPMC10092128 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature