The effect of antenatal corticosteroid use on offspring cardiovascular function: A systematic review.

ABSTRACT:

Background

Antenatal corticosteroids (ACS) are recommended in threatened preterm labour to improve short-term neonatal outcome. Preclinical animal studies suggest detrimental effects of ACS exposure on offspring cardiac development; their effects in humans are unknown.

Objectives

To systematically review the human clinical literature to determine the effects of ACS on offspring cardiovascular function.

Search strategy

A systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in MEDLINE, EMBASE and Cochrane databases.

Selection criteria

Offspring who had been exposed to ACS during fetal life, in comparison with those not receiving steroids, those receiving a placebo or population data, w

SUBMITTER: Sacco A 

PROVIDER: S-EPMC10092187 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature