Systemic Metabolic Alteration Dependent on the Thyroid-Liver Axis in Early PD.

ABSTRACT:

Objective

Parkinson's disease (PD) is a common neurodegenerative disease characterized by initial involvement of the olfactory bulb/amygdala or autonomic nerves followed by nigral degeneration. Although autonomic innervation strictly regulates multiorgan systems, including endocrine functions, circulation, and digestion, how dysautonomia in PD affects systemic metabolism has not been identified. In this study, we tried to estimate the pathogenic linkage of PD by nuclear medicine techniques, trans-omic analysis of blood samples, and cultured cell experiments.

Methods

Thyroid mediastinum ratio of ¹²³ I-metaiodobenzylguanidine (MIBG) scintigraphy was measured in 1,158 patients with PD. Furthermore, serum exosome miRNA transcriptome analysis and plasma metabolome anal

SUBMITTER: Miyamoto K 

PROVIDER: S-EPMC10092289 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature