Dataset Information

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.

ABSTRACT:

Objective

This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.

Methods

Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.

Results

In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.

Conclusions

TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.

SUBMITTER: Papageorgiou M

PROVIDER: S-EPMC10092311 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.

Papageorgiou Maria M Biver Emmanuel E Mareschal Julie J Phillips Nicholas Edward NE Hemmer Alexandra A Biolley Emma E Schwab Nathalie N Manoogian Emily N C ENC Gonzalez Rodriguez Elena E Aeberli Daniel D Hans Didier D Pot Caroline C Panda Satchidananda S Rodondi Nicolas N Ferrari Serge L SL Collet Tinh-Hai TH

Obesity (Silver Spring, Md.) 20221014

<h4>Objective</h4>This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.<h4>Methods</h4>Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight ...[more]

PMID: 36239695

Similar Datasets

Project description:ImportanceTime-restricted eating (TRE) has become increasingly popular, yet longer-term randomized clinical trials have not evaluated its efficacy and safety in patients with type 2 diabetes (T2D).ObjectiveTo determine whether TRE is more effective for weight reduction and glycemic control than daily calorie restriction (CR) or a control condition in adults with T2D.Design, setting, and participantsThis 6-month, parallel-group, randomized clinical trial was performed between January 25, 2022, and April 1, 2023, at the University of Illinois Chicago. Participants were aged 18 to 80 years with obesity and T2D. Data analysis was based on intention to treat.InterventionsParticipants were randomized to 1 of 3 groups: 8-hour TRE (eating 12 to 8 pm only, without calorie counting), CR (25% energy restriction daily), or control.Main outcomes and measuresThe primary outcome measure was change in body weight by month 6. Secondary outcomes included changes in hemoglobin A1c (HbA1c) levels and metabolic risk factors.ResultsSeventy-five participants were enrolled with a mean (SD) age of 55 (12) years. The mean (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 39 (7) and the mean (SD) HbA1c level was 8.1% (1.6%). A total of 53 participants (71%) were women. One participant (1%) was Asian, 30 (40%) were Hispanic White, 40 (53%) were non-Hispanic Black, and 4 (5%) were non-Hispanic White. Participants in the TRE group were adherent with their eating window on a mean (SD) of 6.1 (0.8) days per week, and 17 (68%) in the CR group were adherent with their prescribed calorie goals over 6 months. The mean (SD) reduction in energy intake was -313 (509) kcal/d for TRE, -197 (426) kcal/d for CR, and -16 (439) kcal/d for controls. By month 6, body weight decreased significantly in the TRE group (-3.56% [95% CI, -5.92% to -1.20%]; P = .004) but not the CR group (-1.78% [95% CI, -3.67% to 0.11%]; P = .06), relative to controls. Levels of HbA1c decreased in the TRE (-0.91% [95% CI, -1.61% to -0.20%]) and CR (-0.94% [95% CI, -1.59% to -0.30%]) groups, relative to controls, with no differences between the TRE and CR groups. Time in euglycemic range, medication effect score, blood pressure, and plasma lipid levels did not differ among groups. No serious adverse events were reported.Conclusions and relevanceThis randomized clinical trial found that a TRE diet strategy without calorie counting was effective for weight loss and lowering of HbA1c levels compared with daily calorie counting in a sample of adults with T2D. These findings will need to be confirmed by larger RCTs with longer follow-up.Trial registrationClinicalTrials.gov Identifier: NCT05225337.

Dataset Information

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.

Objective

Methods

Results

Conclusions

Publications

The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.

Similar Datasets

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