Central sensitivity to thyroid hormones is reduced in youths with overweight or obesity and impaired glucose tolerance.

ABSTRACT:

Background

Thyroid hormones (TH) play multiple effects on glucose metabolism. Some recent studies carried out in adult patients suggested an association between altered sensitivity to TH and type 2 diabetes, obesity, and metabolic syndrome. No studies are currently available on the presence of altered sensitivity to the action of TH in youths with prediabetes.

Objective

To evaluate the relationship between sensitivity to TH and impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or glycosylated hemoglobin (HbA1c) ≥ 5.7% in youths with overweight/obesity (OW/OB).

Materials and methods

This cross-sectional study included 805 Caucasian youths with OW or OB (aged 6-18 years) recruited at seven Italian centers for the care of OW/OB. Individuals with TH out of

SUBMITTER: Di Bonito P 

PROVIDER: S-EPMC10092349 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature