Myostatin in idiopathic inflammatory myopathies: Serum assessment and disease activity.

ABSTRACT:

Aims

In idiopathic inflammatory myopathies (IIM), disease activity is difficult to assess, and IIM may induce severe muscle damage, especially in immune-mediated necrotising myopathies (IMNM) and inclusion body myositis (IBM). We hypothesise that myostatin, a negative regulator of muscle mass, could be a new biomarker of disease activity and/or muscle damage.

Methods

Prospective assessment of myostatin protein level in 447 IIM serum samples (dermatomyositis [DM], n = 157; IBM, n = 72; IMNM, n = 125; and antisynthetase syndrome [ASyS], n = 93) and 59 healthy donors (HD) was performed by ELISA. A gene transcript analysis was also carried out on 18 IIM muscle biopsies and six controls to analyse myostatin and myostatin pathway-related gene expression.

Results

IIM patient

SUBMITTER: Mahoudeau A 

PROVIDER: S-EPMC10092350 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature