P2X7 receptor activation impairs antitumour activity of natural killer cells.

ABSTRACT:

Background and purpose

A high number of intratumoural infiltrating natural killer (NK) cells is associated with better survival in several types of cancer, constituting an important first line of defence against tumours. Hypoxia in the core of solid tumours induces cellular stress and ATP release into the extracellular space where it triggers purinergic receptor activation on tumour-associated immune cells. The aim of this study was to assess whether activation of the purinergic receptor P2X7 by extracellular ATP plays a role in the NK cells antitumour activity.

Experimental approach

We carried out in vitro experiments using purified human NK cells triggered through P2X7 by extracellular ATP. NK cell killing activity against the tumour target cells K562 was studied by means

SUBMITTER: Baroja-Mazo A 

PROVIDER: S-EPMC10092446 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature