Numerical and experimental investigation of a lighthouse tip drainage cannula used in extracorporeal membrane oxygenation.

ABSTRACT:

Background

Extracorporeal membrane oxygenation is a life-saving therapy used in case of acute respiratory/circulatory failure. Exposure of blood to non-physiological surfaces and high shear stresses is related to hemolytic damage and platelet activation. A detailed knowledge of the fluid dynamics of the components under different scenarios is thus paramount to assess the thrombogenicity of the circuit.

Methods

An investigation of the flow structures developing in a conventional lighthouse tip (single-staged) drainage cannula was performed with cross-validated computational fluid dynamics and particle image velocimetry. The aim was to quantify the variation in drainage performance and stress levels induced by different fluid models, hematocrit and vessel-to-cannula flow rate

SUBMITTER: Fiusco F 

PROVIDER: S-EPMC10092507 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature