Biosynthesis of geranate via isopentenol utilization pathway in Escherichia coli.

ABSTRACT: Isoprenoids are a large family of natural products with diverse structures, which allow them to play diverse and important roles in the physiology of plants and animals. They also have important commercial uses as pharmaceuticals, flavoring agents, fragrances, and nutritional supplements. Recently, metabolic engineering has been intensively investigated and emerged as the technology of choice for the production of isoprenoids through microbial fermentation. Isoprenoid biosynthesis typically originates in plants from acetyl-coA in central carbon metabolism, however, a recent study reported an alternative pathway, the isopentenol utilization pathway (IUP), that can provide the building blocks of isoprenoid biosynthesis from affordable C5 substrates. In this study, we expressed the IUP in Esc

SUBMITTER: Pan Q 

PROVIDER: S-EPMC10092522 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature