Nucleoli and the nucleoli-centromere association are dynamic during normal development and in cancer.

ABSTRACT: Centromeres are known to cluster around nucleoli in Drosophila and mammalian cells, but the significance of the nucleoli-centromere interaction remains underexplored. To determine whether the interaction is dynamic under different physiological and pathological conditions, we examined nucleolar structure and centromeres at various differentiation stages using cell culture models and the results showed dynamic changes in nucleolar characteristics and nucleoli-centromere interactions through differentiation and in cancer cells. Embryonic stem cells usually have a single large nucleolus, which is clustered with a high percentage of centromeres. As cells differentiate into intermediate states, the nucleolar number increases and the centromere association decreases. In terminally differe

SUBMITTER: Rodrigues A 

PROVIDER: S-EPMC10092642 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature