Liver-related complications before and after successful treatment of chronic hepatitis C virus infection in people with inherited bleeding disorders.

ABSTRACT:

Introduction

With availability of direct-acting antivirals (DAA), most persons with inherited bleeding disorders are currently cured of hepatitis C virus (HCV) infection. The risk of liver-related complications following HCV cure has not been reported for this population.

Aim

Reporting liver-related complications during long-term chronic HCV infection and following sustained virological response (SVR) in this population.

Methods

Retrospective follow-up of a prospective single-centre cohort of HCV antibody-positive persons with inherited bleeding disorders. Primary endpoint was liver-related complications [hepatocellular carcinoma (HCC), decompensated cirrhosis, bleeding gastroesophageal varices]. Liver-related complications were reported separately during chronic HCV

SUBMITTER: Isfordink CJ 

PROVIDER: S-EPMC10092673 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature