Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects the cardiovascular system, causing vascular damage and thromboembolic events in critical patients. Endothelial dysfunction represents one of the first steps in response to COVID-19 that might lead to cardiovascular complications and long-term sequelae. However, despite the enormous efforts in the last two years, the molecular mechanisms involved in such processes remain poorly understood. Herein, we analyzed the protein changes taking place in endothelial colony forming cells (ECFCs) after the incubation with the serum from individuals infected with COVID-19, whether asymptomatic or critical patients, by application of a label free-quantitative proteomics approach. Specifically, ECFCs from healthy

SUBMITTER: Beltran-Camacho L 

PROVIDER: S-EPMC10092762 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature