Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice.

ABSTRACT: Rationale: Macrophages play a central role in the development and progression of nonalcoholic fatty liver disease (NAFLD). Studies have shown that Notch signaling mediated by transcription factor recombination signal binding protein for immunoglobulin kappa J region (RBP-J), is implicated in macrophage activation and plasticity. Naturally, we asked whether Notch signaling in macrophages plays a role in NAFLD, whether regulating Notch signaling in macrophages could serve as a therapeutic strategy to treat NAFLD. Methods: Immunofluorescence staining was used to detect the changes of macrophage Notch signaling in the livers of human patients with NAFLD and choline deficient amino acid-defined (CDAA) diet-fed mice. Lyz2-Cre RBP-J^flox or wild-type C57BL/6 male mice were

SUBMITTER: Ding J 

PROVIDER: S-EPMC10092768 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature