Characteristics and clinical outcomes of patients with acute heart failure with a supranormal left ventricular ejection fraction.

ABSTRACT:

Aim

Recent data suggest that guideline-directed medical therapy of patients with heart failure (HF) with reduced ejection fraction (HFrEF) might improve clinical outcomes in patients with HF up to a left ventricular ejection fraction (LVEF) of 55-65%, whereas patients with higher LVEF do not seem to benefit. Recent data have shown that LVEF may have a U-shaped relation with outcome, with poorer outcome also in patients with supranormal values. This suggests that patients with supranormal LVEF may be a distinctive group of patients.

Methods and results

RELAX-AHF-2 was a multicentre, placebo-controlled trial on the effects of serelaxin on 180-day cardiovascular (CV) mortality and worsening HF at day 5 in patients with acute HF. Echocardiograms were performed at hospital admiss

SUBMITTER: van Essen BJ 

PROVIDER: S-EPMC10092799 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature