Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO₂ block or a xenogeneic graft in chronic alveolar defects.

ABSTRACT:

Objectives

To evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic noncontained bone defects using a nonresorbable TiO₂ block.

Materials and methods

Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomization: TiO₂ block: TiO₂ -scaffold and a collagen membrane, DBBM particulates: Deproteinized bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha-smooth muscle actin (α-SMA),

SUBMITTER: Thieu MKL 

PROVIDER: S-EPMC10092822 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature