Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells.

ABSTRACT: Exposure to fine particulate matter (PM_2.5 ) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM_2.5 exaggerate adipose inflammation and insulin resistance in mice with diet-induced obesity. Here, we elucidate the hypothesis that such systemic effects may be triggered by adhered particle components affecting adipose tissue directly. Studying adipocytes differentiated from primary human mesenchymal stem cells, we found that lipophilic organic chemicals (OC) from diesel exhaust particles induced inflammation-associated genes and increased secretion of the chemokine CXLC8/interleukin-8 as well as matrix metalloprotease 1. The oxidative stress response gene haem oxygenase-1 an

SUBMITTER: Brinchmann BC 

PROVIDER: S-EPMC10092867 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature