^99m Technetium-pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study.

ABSTRACT:

Introduction/aims

Transthyretin amyloidosis (ATTR) proteins can infiltrate skeletal muscle and infrequently cause a myopathy. ^99m Technetium-pyrophosphate (^99m Tc-PYP) is a validated biomarker for cardiac involvement in variant and wild-type ATTR (ATTRv and ATTRwt, respectively). The aim of this study was to test the hypothesis that ^99m Tc-PYP is a biomarker for muscle burden of ATTR.

Methods

Radioisotope uptake in the deltoid muscles of patients with ATTR was compared to uptake in control subjects without amyloidosis in a retrospective study. ^99m Tc-PYP scans were evaluated in 11 patients with ATTR (7 ATTRv, 4 ATTRwt) and 14 control subjects. Mean count (MC) values were measured in circular regions of interest (ROIs) 2.5-3.8 cm

SUBMITTER: Wlodarski R 

PROVIDER: S-EPMC10092886 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature