Spexin in the European sea bass, Dicentrarchus labrax: Characterization, brain distribution, and interaction with Gnrh and Gnih neurons.

ABSTRACT: Spexin (Spx) is a recently characterized neuropeptide implicated in multiple physiological processes in vertebrates, including reproduction, food intake, and regulation of anxiety and stress. Two orthologs (Spx1 and Spx2) are present in some nonmammalian vertebrates, including teleosts. However, information on the distribution of Spx in the brain and its interactions with other neuroendocrine systems in fish is still scarce. In this work, we cloned and sequenced the sea bass (Dicentrarchus labrax) Spx1, which included a 27 aa signal peptide and a mature peptide of 14 aa that is C-terminal amidated. spx1 transcripts were higher in the diencephalon/caudal preoptic area/hypothalamus and medulla but were also detected in the olfactory bulbs, telencephalon/rostral preoptic area, optic tectum/te

SUBMITTER: Paullada-Salmeron JA 

PROVIDER: S-EPMC10092896 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature