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Stem cell-derived exosome versus stem cell therapy.


ABSTRACT: Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enable their clinical translation.

SUBMITTER: Zhang K 

PROVIDER: S-EPMC10092910 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Stem cell-derived exosome versus stem cell therapy.

Zhang Kaiyue K   Cheng Ke K  

Nature reviews bioengineering 20230412


Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enabl  ...[more]

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