Distinct phenotypes of multisystem inflammatory syndrome in children: a cohort study.

ABSTRACT:

Background

Multisystem inflammatory syndrome in children (MIS-C) is a severe disease with an unpredictable course and a substantial risk of cardiogenic shock. Our objectives were to (a) compare MIS-C phenotypes across the COVID-19 pandemic, (b) identify features associated with intensive care need and treatment with biologic agents.

Methods

Youth aged 0-18 years, fulfilling the World Health Organization case definition of MIS-C, and admitted to the Alberta Children's Hospital during the first four waves of the COVID-19 pandemic (May 2020-December 2021) were included in this cohort study. Demographic, clinical, biochemical, imaging, and treatment data were captured.

Results

Fifty-seven MIS-C patients (median age 6 years, range 0-17) were included. Thirty patients (53%)

SUBMITTER: Renson T 

PROVIDER: S-EPMC10092941 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature