Precision Killing of M2 Macrophages with Phage-Displayed Peptide-Photosensitizer Conjugates.

ABSTRACT: Among the immunosuppressive cells recruited to the tumor microenvironment, macrophages are particularly abundant and involved in angiogenesis, metastasis, and resistance to current cancer therapies. A strategy that simultaneously targets tumor cells and macrophages, particularly pro-tumoral M2 macrophages, would have significant clinical impact for various types of solid malignancies. By the use of phage display technology, we have recently developed a synthetic peptide, named NW, which binds to M1 and M2 macrophages with high affinity. Additional affinity selection on M2 macrophages identified only dominant peptides whose binding motifs are similar to that of the NW peptide. To reduce the frequency of selecting such dominating peptides, the peptide library was affinity selected on M2 macr

SUBMITTER: Sioud M 

PROVIDER: S-EPMC10093000 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature