Oncolytic Adenoviruses Armed with Co-Stimulatory Molecules for Cancer Treatment.

ABSTRACT: In clinical trials, adenovirus vectors (AdVs) are commonly used platforms for human gene delivery therapy. High genome capacity and flexibility in gene organization make HAdVs suitable for cloning. Recent advancements in molecular techniques have influenced the development of genetically engineered adenovirus vectors showing therapeutic potential. Increased molecular understanding of the benefits and limitations of HAdVs in preclinical research and clinical studies is a crucial point in the engineering of refined oncolytic vectors. This review presents HAdV species (A-G) used in oncotherapy. We describe the adenovirus genome organizations and modifications, the possibilities oncolytic viruses offer, and their current limitations. Ongoing and ended clinical trials based on oncolytic adenovi

SUBMITTER: Gryciuk A 

PROVIDER: S-EPMC10093006 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature