TCF12 Deficiency Impairs the Proliferation of Glioblastoma Tumor Cells and Improves Survival.

ABSTRACT: Isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM) is the most common and aggressive primary brain tumor which carries a very poor overall prognosis and is universally fatal. Understanding the transcriptional regulation of the proliferation of GBM tumor cells is critical for developing novel and effective treatments. In this study, we investigate the role of the transcription factor TCF12 in the regulation of GBM proliferation using human and murine GBM cell lines and an in vivo GBM xenograft model. Our study shows that TCF12 deficiency severely impairs proliferation of tumor cells in vitro by disrupting/blocking the G1 to S phase transition. We also discover that TCF12 loss significantly improves animal survival and that TCF12-deficient tumors grow much slower in vivo. Overexpres

SUBMITTER: Pang Y 

PROVIDER: S-EPMC10093168 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature