Ocular Delivery of Therapeutic Agents by Cell-Penetrating Peptides.

ABSTRACT: Cell-penetrating peptides (CPPs) are short peptides with the ability to translocate through the cell membrane to facilitate their cellular uptake. CPPs can be used as drug-delivery systems for molecules that are difficult to uptake. Ocular drug delivery is challenging due to the structural and physiological complexity of the eye. CPPs may be tailored to overcome this challenge, facilitating cellular uptake and delivery to the targeted area. Retinal diseases occur at the posterior pole of the eye; thus, intravitreal injections are needed to deliver drugs at an effective concentration in situ. However, frequent injections have risks of causing vision-threatening complications. Recent investigations have focused on developing long-acting drugs and drug delivery systems to reduce the frequency

SUBMITTER: Nhan NTT 

PROVIDER: S-EPMC10093283 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature