Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region.

ABSTRACT:

Background

Human papillomavirus (HPV) status is the most important predictor of survival in oropharyngeal squamous cell carcinoma (OPSCC). In patients with cervical lymph node metastases of squamous cell carcinoma of unknown origin (CUP_HNSCC), much less is known.

Methods

We assessed a consecutive cohort of CUP_HNSCC diagnosed from 2000-2018 for HPV DNA, mRNA, p16^INK4a (p16) expression, and risk factors to identify prognostic classification markers.

Results

In 32/103 (31%) CUP_HNSCC, p16 was overexpressed, and high-risk HPV DNA was detected in 18/32 (56.3%). This was mostly consistent with mRNA detection. In recursive partitioning analysis, CUP_HNSCC patients were classified into three risk groups according to perform

SUBMITTER: Wagner S 

PROVIDER: S-EPMC10093301 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature