Microparticle Phosphatidylserine Mediates Coagulation: Involvement in Tumor Progression and Metastasis.

ABSTRACT: Tumor progression and cancer metastasis has been linked to the release of microparticles (MPs), which are shed upon cell activation or apoptosis and display parental cell antigens, phospholipids such as phosphatidylserine (PS), and nucleic acids on their external surfaces. In this review, we highlight the biogenesis of MPs as well as the pathophysiological processes of PS externalization and its involvement in coagulation activation. We review the available evidence, suggesting that coagulation factors (mainly tissue factor, thrombin, and fibrin) assist in multiple steps of tumor dissemination, including epithelial-mesenchymal transition, extracellular matrix remodeling, immune escape, and tumor angiogenesis to support the formation of the pre-metastatic niche. Platelets are not just bysta

SUBMITTER: Jing H 

PROVIDER: S-EPMC10093313 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature