Circulating miRNAs in Women with Polycystic Ovary Syndrome: A Longitudinal Cohort Study.

ABSTRACT:

Background

Women with polycystic ovary syndrome (PCOS) often change their metabolic profile over time to decrease levels of androgens while often gaining a propensity for the development of the metabolic syndrome. Recent discoveries indicate that microRNAs (miRNAs) play a role in the development of PCOS and constitute potential biomarkers for PCOS. We aimed to identify miRNAs associated with the development of an impaired metabolic profile in women with PCOS, in a follow-up study, compared with women without PCOS.

Methods and materials

Clinical measurements of PCOS status and metabolic disease were obtained twice 6 years apart in a cohort of 46 women with PCOS and nine controls. All participants were evaluated for degree of metabolic disease (hypertension, dyslipidemia, cent

SUBMITTER: Udesen PB 

PROVIDER: S-EPMC10093401 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature