New Findings: Hindlimb Unloading Causes Nucleocytoplasmic Ca²⁺ Overload and DNA Damage in Skeletal Muscle.

ABSTRACT: Disuse atrophy of skeletal muscle is associated with a severe imbalance in cellular Ca²⁺ homeostasis and marked increase in nuclear apoptosis. Nuclear Ca²⁺ is involved in the regulation of cellular Ca²⁺ homeostasis. However, it remains unclear whether nuclear Ca²⁺ levels change under skeletal muscle disuse conditions, and whether changes in nuclear Ca²⁺ levels are associated with nuclear apoptosis. In this study, changes in Ca²⁺ levels, Ca²⁺ transporters, and regulatory factors in the nucleus of hindlimb unloaded rat soleus muscle were examined to investigate the effects of disuse on nuclear Ca²⁺ homeostasis and apoptosis. Results showed that, after hindlimb unloading, the nuclear envelope Ca²⁺

SUBMITTER: Yang H 

PROVIDER: S-EPMC10093444 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature