Epigenetic Rewiring of Metastatic Cancer to the Brain: Focus on Lung and Colon Cancers.

ABSTRACT: Distant metastasis occurs when cancer cells adapt to a tissue microenvironment that is different from the primary organ. This process requires genetic and epigenetic changes in cancer cells and the concomitant modification of the tumor stroma to facilitate invasion by metastatic cells. In this study, we analyzed differences in the epigenome of brain metastasis from the colon (n = 4) and lung (n = 14) cancer and we compared these signatures with those found in primary tumors. Results show that CRC tumors showed a high degree of genome-wide methylation compared to lung cancers. Further, brain metastasis from lung cancer deeply activates neural signatures able to modify the brain microenvironment favoring tumor cells adaptation. At the protein level, brain metastases from lung cancer show exp

SUBMITTER: Morotti A 

PROVIDER: S-EPMC10093491 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature