Precision Surgery of Colorectal Liver Metastases in the Current Era: A Systematic Review.

ABSTRACT: Liver resection for colorectal liver metastases (CRLM) is widely considered the treatment with the highest curative potential. However, not all patients derive the same oncological benefit, underlining the need for better patient stratification and treatment allocation. In this context, we performed a systematic review of the literature to determine the role of RAS status in selecting the optimal surgical strategy. Evidence comparing anatomical with non-anatomical resections depending on RAS mutational status was scarce and conflicting, with two studies reporting superiority in mutated RAS (mutRAS) patients and two studies reporting equivalent outcomes. The rate of incomplete microscopic resection (R1) was found to be increased among mutRAS patients, possibly due to higher micrometastatic

SUBMITTER: Papaconstantinou D 

PROVIDER: S-EPMC10093504 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature