Exploring Spatial Heterogeneity of Immune Cells in Nasopharyngeal Cancer.

ABSTRACT: Nasopharyngeal cancer (NPC) is a malignant tumor. In a recent publication, we described the presence and distribution of CD8⁺ T cells in NPC and used the information to identify 'inflamed', 'immune-excluded', and 'desert' immune phenotypes, where 'inflamed' and 'immune-excluded' NPCs were correlated with CD8 T cell infiltration and survival. Arguably, more detailed and, in particular, spatially resolved data are required for patient stratification and for the identification of new treatment targets. In this study, we investigate the phenotype of CD45⁺ leukocytes in the previously analyzed NPC samples by applying multiplexed tissue analysis to assess the spatial distribution of cell types and to quantify selected biomarkers. A total of 47 specified regions-of-interest

SUBMITTER: Sobti A 

PROVIDER: S-EPMC10093565 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature