The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.

ABSTRACT: Integrins are a group of heterodimers consisting of α and β subunits that mediate a variety of physiological activities of immune cells, including cell migration, adhesion, proliferation, survival, and immunotolerance. Multiple types of integrins act differently on the same immune cells, while the same integrin may exert various effects on different immune cells. In the development of cancer, integrins are involved in the regulation of cancer cell proliferation, invasion, migration, and angiogenesis; conversely, integrins promote immune cell aggregation to mediate the elimination of tumors. The important roles of integrins in cancer progression have provided valuable clues for the diagnosis and targeted treatment of cancer. Furthermore, many integrin inhibitors have been investigated in cl

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10093897 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature