Inhibitory Effects of Thermolysis Transformation Products of Rotenone on Nitric Oxide Production.

ABSTRACT: Rotenone, isolated from Derris, Lonchocarpus, and Tephrosia from the family Fabaceae, has been shown to have a variety of biological properties and is used in various agricultural industries as a potent biopesticide. However, recent reports have demonstrated that rotenone has the potential to cause several adverse effects such as a neurodegenerative disease. This study aimed to induce thermolysis of the biopesticide rotenone and enhance the functionality of the degraded products. Rotenone (1) was degraded after autoclaving for 12 h, and the thermolytic reactants showed enhanced anti-inflammatory capacity against nitric oxide (NO) production. The structures of the newly modified products were spectroscopically determined. The thermal reaction products included va

SUBMITTER: Jeong GH 

PROVIDER: S-EPMC10093917 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature