Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization.

ABSTRACT: Overcoming the short lifespan of current dental adhesives remains a significant clinical need. Adhesives rely on formation of the hybrid layer to adhere to dentin and penetrate within collagen fibrils. However, the ability of adhesives to achieve complete enclosure of demineralized collagen fibrils is recognized as currently unattainable. We developed a peptide-based approach enabling collagen intrafibrillar mineralization and tested our hypothesis on a type-I collagen-based platform. Peptide design incorporated collagen-binding and remineralization-mediating properties using the domain structure conservation approach. The structural changes from representative members of different peptide clusters were generated for each functional domain. Common signatures associated with secondary struc

SUBMITTER: Cloyd AK 

PROVIDER: S-EPMC10093982 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature