A nanoparticle-coated microfluidic chip for automated, non-destructive extraction of encapsulated DNA in data storage.

ABSTRACT: DNA data storage based on tubes as physical storage carriers has been developed to solve the problem of the exponential growth of information. Compact disk (CD)-microfluidics that employs centrifugal forces for fluidic manipulation offers an attractive alternative that integrates complex assays onto a miniaturized platform to result in automation for DNA data storage. In this work, we develop a CD microfluidic chip modified with nanoparticles for accurate fluid flow control. The nanoparticle coating turns microchannels into valves or pumps, which reduces the error in fluidic control from 62% to 6%. Based on the nanoparticle coating, the chip integrates demineralization, nucleic acid amplification, and re-mineralization functions for automated, non-destructive information extraction. We pro

SUBMITTER: Geng C 

PROVIDER: S-EPMC10094012 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature