A novel variant in BCL11B in an individual with neurodevelopmental delay: A case report.

ABSTRACT:

Background

B-Cell CLL/Lymphoma 11B (BCL11B) is a C₂ H₂ zinc finger transcription factor that has broad biological functions and is essential for the development of the immune system, neural system, cardiovascular system, dermis, and dentition. Variants of BCL11B have been found in patients with neurodevelopmental disorders and immunodeficiency.

Materials and methods

Whole-exome sequencing (WES) and clinical examinations were performed to identify the etiology of our patient. A variant in the BCL11B gene, NM_138576.4: c.1206delG (p.Phe403Serfs*2) was found and led to frameshift truncation.

Results

We reported a male patient with developmental delay and cerebral palsy who carried the BCL11B variant. The detailed clinical features, such as brain str

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10094078 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature