Ab Initio Modelling of the Structure of ToxA-like and MAX Fungal Effector Proteins.

ABSTRACT: Pathogenic fungal diseases in crops are mediated by the release of effector proteins that facilitate infection. Characterising the structure of these fungal effectors is vital to understanding their virulence mechanisms and interactions with their hosts, which is crucial in the breeding of plant cultivars for disease resistance. Several effectors have been identified and validated experimentally; however, their lack of sequence conservation often impedes the identification and prediction of their structure using sequence similarity approaches. Structural similarity has, nonetheless, been observed within fungal effector protein families, creating interest in validating the use of computational methods to predict their tertiary structure from their sequence. We used Rosetta ab initio modelli

SUBMITTER: Rozano L 

PROVIDER: S-EPMC10094246 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature