Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology.

ABSTRACT: Pelvic organ prolapse (POP) represents a major health care burden in women, but its underlying pathophysiological mechanisms have not been elucidated. We first used a case-control design to perform an exome chip study in 526 women with POP and 960 control women to identify single nucleotide variants (SNVs) associated with the disease. We then integrated the functional interactions between the POP candidate proteins derived from the exome chip study and other POP candidate molecules into a molecular landscape. We found significant associations between POP and SNVs in 54 genes. The proteins encoded by 26 of these genes fit into the molecular landscape, together with 43 other POP candidate molecules. The POP landscape is located in and around epithelial cells and fibroblasts of the urogenital

SUBMITTER: Kluivers KB 

PROVIDER: S-EPMC10094264 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature