An Innovative Fluid Dynamic System to Model Inflammation in Human Skin Explants.

ABSTRACT: Skin is a major administration route for drugs, and all transdermal formulations must be tested for their capability to overcome the cutaneous barrier. Therefore, developing highly reliable skin models is crucial for preclinical studies. The current in vitro models are unable to replicate the living skin in all its complexity; thus, to date, excised human skin is considered the gold standard for in vitro permeation studies. However, skin explants have a limited life span. In an attempt to overcome this problem, we used an innovative bioreactor that allowed us to achieve good structural and functional preservation in vitro of explanted human skin for up to 72 h. This device was then used to set up an in vitro inflammatory model by applying two distinct agents mimicking either exogenous or e

SUBMITTER: Galvan A 

PROVIDER: S-EPMC10094544 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature