Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma.

ABSTRACT: Multiple myeloma (MM) is the second most prevalent hematologic malignancy. In the past few years, the survival of MM patients has increased due to the emergence of novel drugs and combination therapies. Nevertheless, one of the significant obstacles in treating most MM patients is drug resistance, especially for individuals who have experienced relapses or developed resistance to such cutting-edge treatments. One of the critical processes in developing drug resistance in MM is autophagic activity, an intracellular self-digestive process. Several possible strategies of autophagy involvement in the induction of MM-drug resistance have been demonstrated thus far. In multiple myeloma, it has been shown that High mobility group box protein 1 (HMGB1)-dependent autophagy can contribute to drug re

SUBMITTER: Bashiri H 

PROVIDER: S-EPMC10094562 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature