Effect of Electric Field on α-Synuclein Fibrils: Revealed by Molecular Dynamics Simulations.

ABSTRACT: The self-association of amylogenic proteins to the fibril form is considered a pivotal factor in the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). PD causes unintended or uncontrollable movements in its common symptoms. α-synuclein is the major cause of PD development and thus has been the main target of numerous studies to suppress and sequester its expression or effectively degrade it. Nonetheless, to date, there are no efficient and proven ways to prevent pathological protein aggregation. Recent investigations proposed applying an external electric field to interrupt the fibrils. This method is a non-invasive approach that has a certain benefit over others. We performed molecular dynamics (MD) simulations by applying an electric field on highly toxic fi

SUBMITTER: Razzokov J 

PROVIDER: S-EPMC10094641 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature