Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells.

ABSTRACT: Arginine methylation is a form of posttranslational modification that regulates many cellular functions such as development, DNA damage repair, inflammatory response, splicing, and signal transduction, among others. Protein arginine methyltransferase 5 (PRMT5) is one of nine identified methyltransferases, and it can methylate both histone and non-histone targets. It has pleiotropic functions, including recruitment of repair machinery to a chromosomal DNA double strand break (DSB) and coordinating the interplay between repair and checkpoint activation. Thus, PRMT5 has been actively studied as a cancer treatment target, and small molecule inhibitors of its enzymatic activity have already been developed. In this report, we analyzed all reported PRMT5 mutations appearing in cancer cells using

SUBMITTER: Rasheed S 

PROVIDER: S-EPMC10094674 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature